2020

Mohammad A, Alshawaf E, Marafie SK, Abu-Farha M, Abubaker J, Al-Mulla F. Higher binding affinity of Furin to SARS-CoV-2 spike (S) protein D614G could be associated with higher SARS-CoV-2 infectivity. Int J Infect Dis. 2020 Oct 16:S1201-9712(20)32237-2. doi: 10.1016/j.ijid.2020.10.033. Epub ahead of print. PMID: 33075532; PMCID: PMC7567667.

Kochumon S, Arefanian H, Azim R, Shenouda S, Jacob T, Abu Khalaf N, Al-Rashed F, Hasan A, Sindhu S, Al-Mulla F, Ahmad R. Stearic Acid and TNF-α Co-Operatively Potentiate MIP-1α Production in Monocytic Cells via MyD88 Independent TLR4/TBK/IRF3 Signaling Pathway. Biomedicines. 2020 Oct 9;8(10):403. doi: 10.3390/biomedicines8100403. PMID: 33050324; PMCID: PMC7600458.

Hasan A, Kochumon S, Al-Ozairi E, Tuomilehto J, Al-Mulla F, Ahmad R. Correlation Profile of Suppression of Tumorigenicity 2 and/or Interleukin-33 with Biomarkers in the Adipose Tissue of Individuals with Different Metabolic States. Diabetes Metab Syndr Obes. 2020 Oct 20;13:3839-3859. doi: 10.2147/DMSO.S251978. PMID: 33116731; PMCID: PMC7586022.

Sina M, Ghorbanoghli Z, Abedrabbo A, Al-Mulla F, Sghaier RB, Buisine MP, Cortas G, Goshayeshi L, Hadjisavvas A, Hammoudeh W, Hamoudi W, Jabari C, Loizidou MA, Majidzadeh-A K, Marafie MJ, Muslumov G, Rifai L, Seir RA, Talaat SM, Tunca B, Ziada-Bouchaar H, Velthuizen ME, Sharara AI, Ahadova A, Georgiou D, Vasen HFA; Middle East Network on Hereditary Colorectal Cancer (HCCN-ME). Identification and management of Lynch syndrome in the Middle East and North African countries: outcome of a survey in 12 countries. Fam Cancer. 2020 Oct 24. doi: 10.1007/s10689-020-00211-3. Epub ahead of print. PMID: 33098072.

Alkandari A, Alarouj M, Elkum N, Sharma P, Devarajan S, Abu-Farha M, Al-Mulla F, Tuomilehto J, Bennakhi A. Adult Diabetes and Prediabetes Prevalence in Kuwait: Data from the Cross-Sectional Kuwait Diabetes Epidemiology Program. J Clin Med. 2020 Oct 25;9(11):E3420. doi: 10.3390/jcm9113420. PMID: 33113867.

Alahmad B, Al-Shammari AA, Bennakhi A, Al-Mulla F, Ali H. Fasting Blood Glucose and COVID-19 Severity: Nonlinearity Matters. Diabetes Care. 2020 October. Epub. https://doi.org/10.2337/dc20-1941

Al-Rashed F, Ahmad Z, Thomas R, Melhem M, Snider AJ, Obeid LM, Al-Mulla F, Hannun YA, Ahmad R. Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α. Sci Rep. 2020 Oct 8;10(1):16802. doi:10.1038/s41598-020-73912-5. PMID: 33033337.

Abu-Farha M, Ghosh A, Al-Khairi I, Madiraju SRM, Abubakr J, Prentki M. The multi-faces of Angptl8 in health and disease: Novel functions beyond lipoprotein lipase modulation. Prog Lipid Res. 2020 Oct 2;80:101067. doi: 10.1016/j.plipres.2020.101067. Epub ahead of print. PMID: 33011191

Kochumon S, Al Madhoun A, Al-Rashed F, Thomas R, Sindhu S, Al-Ozairi E, Al- Mulla F, Ahmad R. Elevated adipose tissue associated IL-2 expression in obesity correlates with metabolic inflammation and insulin resistance. Sci Rep. 2020 Oct 1;10(1):16364. doi: 10.1038/s41598-020-73347-y. PMID: 33004937; PMCID: PMC7530670.

Zhang Q, Bastard P, Liu Z, ... Al-Mulla F, et al. Inborn errors of type I IFN immunity in patients with life-threaten ng COVID-19. Science. 2020 Oct 23;370(6515):eabd4570. doi: 10.1126/science.abd4570.

Hebbar P, Abubaker JA, Abu-Farha M, Alsmadi O, Elkum N, Alkayal F, John SE, Channanath A, Iqbal R, Pitkaniemi J, Tuomilehto J, Sladek R, Al-Mulla F, Thanaraj TA. Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population. Hum Genet. 2020 Sep 9. doi: 10.1007/s00439-020-02222-7. Epub ahead of print. PMID: 32902719.

Al Madhoun A, Marafie SK, Haddad D, Melhem M, Abu-Farha M, Ali H, Sindhu S, Atari M, Al-Mulla F. Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton's Jelly-Derived Mesenchymal Stem Cells. Int J Mol Sci. 2020 Sep 3;21(17):E6437. doi: 10.3390/ijms21176437. PMID: 32899389.

Alghounaim M, Almazeedi S, Al Youha S, Papenburg J, Alowaish O, AbdulHussain G, Al-Shemali R, Albuloushi A, Alzabin S, Al-Wogayan K, Al-Mutawa Y, Al-Sabah S. Low-Cost Polyester-Tipped 3-Dimensionally-Printed Nasopharyngeal Swab for the Diagnosis of Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2). J Clin Microbiol. 2020 Aug 12:JCM.01668-20. doi: 10.1128/JCM.01668-20.Epub ahead of print. PMID: 32817232.

Hasan A, Aldhahi W. Soluble Suppression of Tumorigenicity 2 is Directly Correlated with Glycated Hemoglobin in Individuals with an Average glycemia in the Normal/Prediabetes Range. Diabetes Metab Syndr Obes. 2020 Aug3;13:2711-2718. doi: 10.2147/DMSO.S251135. PMID: 32801817; PMCID: PMC7413703.

Alterki A, Joseph S, Thanaraj TA, Al-Khairi I, Cherian P, Channanath A, Sriraman D, Ebrahim MAK, Ibrahim A, Tiss A, Al-Mulla F, Rahman AMA, Abubaker J, Abu-Farha M. Targeted Metabolomics Analysis on Obstructive Sleep Apnea Patients after Multilevel Sleep Surgery. Metabolites. 2020 Sep 1;10(9):E358. doi:10.3390/metabo10090358. PMID: 32882816.

Mohammad A, Marafie SK, Alshawaf E, Abu-Farha M, Abubaker J, Al-Mulla F. Structural analysis of ACE2 variant N720D demonstrates a higher binding affinity to TMPRSS2. Life Sci. 2020 Aug 5;259:118219. doi: 10.1016/j.lfs.2020.118219. Epub ahead of print. PMID: 32768580; PMCID: PMC7405906.

Al-Kandari H, Al-Abdulrazzaq D, Al-Jaser F, Al-Mulla F, Davidsson L. Rabson-Mendenhall Syndrome in a brother-sister pair in Kuwait: Diagnosis and 5 year follow up. Prim Care Diabetes. 2020 Aug 22:S1751-9918(20)30234-5. doi:10.1016/j.pcd.2020.07.012. Epub ahead of print. PMID: 32843252.

Al Shawaf E, Al-Ozairi E, Al-Asfar F, Mohammad A, Al-Beloushi S, Devarajan S, Al-Mulla F, Abubaker J, Arefanian H. Atherogenic Index of Plasma (AIP) a Tool to Assess Changes in Cardiovascular Disease Risk Post Laparoscopic Sleeve Gastrectomy. J Diabetes Res. 2020 Aug 1;2020:2091341. doi: 10.1155/2020/2091341.PMID: 32832558; PMCID: PMC7422485.

Al-Rashed F, Sindhu S, Arefanian H, Al Madhoun A, Kochumon S, Thomas R, Al-Kandari S, Alghaith A, Jacob T, Al-Mulla F, Ahmad R. Repetitive Intermittent Hyperglycemia Drives the M1 Polarization and Inflammatory Responses in THP-1 Macrophages Through the Mechanism Involving the TLR4-IRF5 Pathway. Cells. 2020 Aug 12;9(8):E1892. doi: 10.3390/cells9081892. PMID: 32806763; PMCID: PMC7463685.

Abdel-Halim SM, Al Madhoun A, Nizam R, Melhem M, Cherian P, Al-Khairi I, Haddad D, Abu-Farha M, Abubaker J, Bitar MS, Al-Mulla F. Increased Plasma Levels of Adenylate Cyclase 8 and cAMP Are Associated with Obesity and Type 2 Diabetes: Results from a Cross-Sectional Study. Biology (Basel). 2020 Aug 24;9(9):E244.doi: 10.3390/biology9090244. PMID: 32847122.